Integrated decision strategies for skin sensitization hazard
نویسندگان
چکیده
منابع مشابه
Integrated Testing Strategies for Skin Sensitization Hazard and Potency Assessment—State of the Art and Challenges
The paper provides an overview of existing Integrated Testing Strategies (ITS) for assessing hazard and potency of skin sensitization. The ITS research is active, diverse and constantly evolving as new assays are being developed and new mechanistic insights are discovered. Despite the need to assess potency, the majority of the ITS approaches developed to date assess hazard only. Reasons for th...
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Non-animal test methods for skin sensitization have to consider the complex interactions of chemicals with the different parts of the skin immune system (Cumberbatch et al., 1992). A few chemicals act as prohaptens and can be converted to a hapten by oxidation, skin metabolism, or ultraviolet radiation (Karschuk et al., 2010). the hapten (parent or converted chemical) may penetrate the skin and...
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ژورنال
عنوان ژورنال: Journal of Applied Toxicology
سال: 2017
ISSN: 0260-437X
DOI: 10.1002/jat.3572